Causes of Generalized Itching

Generalized Pruritus: Generalized itch may mean widespread itch in various locations, or may even refer to “itching all over”. Skin rash is a common cause of itch, but there are also various systemic disorders that may affect the skin.

Skin Disorders: Generalized itching may be caused by various skin conditions, including numerous causes of skin rash, such as:

See also the causes of related skin symptoms:

Note that an underlying skin rash needs to be distinguished from minor skin damage created by the patient scratching their itch. The absence of rash often indicates a systemic disorder as the cause.

Liver and Biliary Disorders: Any cause of jaundice may cause skin itching, although there are usually other symptoms of jaundice, such as yellowing skin and yellowing eyes. Hence, almost any type of liver disease may cause itch. Causes include:

  • Jaundice
  • Obstructive jaundice
  • Liver disease
  • Hepatitis
  • Liver failure
  • Liver cancer
  • Metastatic liver cancer
  • Hepatobiliary disease
  • Biliary cirrhosis
  • Gallbladder disease

Other Disorders: Various other systemic disorders or organ-specific disorder may also affect the skin, resulting in generalized itch:

Other Causes: Various other causes of widespread itching include:



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Note: This site is for informational purposes only and is not medical advice. See your doctor or other qualified medical professional for all your medical needs.